Medical net May 8, the tetanus antitoxin, glucose injection... These well known drug, drug trading center in guangdong (hereinafter referred to as the guangdong drug delivery center) on May 2, released a list is labeled "urgent (rob) save drug". However, they are listed on this list because of corporate "broken confessions". 

 

Reporter noticed that listed in the "cut off" list of urgent (rob) save a total of 61 drug product gauge (refers to the drug specifications, such as dose size, dosage forms, etc.), and the listing shows that as many as 1004 product rules of drugs outages. 

 

Why is the "life-saving drug" broken? 

 

The cost of raw materials for medicines has risen 

 

"Guangdong is a big province of medicine. Who wants to lose business? Companies don't want to do it, they dare not do it." In the face of the reporter's interview, once Ren Guangdong a long-established drug firms chairman liu yun (a pseudonym) the truth, not don't want to do business company, but the cost of production and the bid price inversion were let the enterprise did not produce power. The daily business news reporter found that the examples of drug companies' reluctance to pay and not to supply were common in all parts of the country. In May 2016, guangdong medicine center had not in accordance with the contract, 806 of the public product rules of drugs, and clearly pointed out that if the public notice period after the end not on time delivery, the goods will be cancelled entry qualification in guangdong province for two years. In addition, there have been many cases in which drug companies have been publicly named in the past. 

 

Medicine circulation association secretary general of hunan province Huang Xiuxiang had earlier told reporters that as a drug consumption in guangdong province, medical institutions purchase quantity is very large, if the drug companies to win the market and survive, in the ability to make money in other provinces are not too bad. 

 

But now it is a "hot potato", and what is the secret of the "broken up" of so many drugs? Reporter contacted nearly 10 in a "cut off" on the list of companies, which in addition to the two considered "cut off" because of distribution enterprises, all the rest of the respondents will be the focus points to the cost of production. 

 

Liu yun told reporters that drug companies supply drugs or supply not in time there are two major part of the reason: first, the production cost especially the raw material cost rise too much; Second, the raw material is a monopoly. , he said, drug procurement bidding price theory is scientific, reference standards have the average price of around the key provinces and cities, into the market, and negotiation, but due to the economic activity of the drug with lag, the bidding price reference data is often in the past four or five years, but the cost of production, especially the cost of raw materials is rising year by year, and even double. In addition to the policies such as the new GMP standard certification and the consistency evaluation, the upgrade of the enterprise to the workshop and the product, also promoted the cost of medicine. 

 

Li yun knows the cost of raw materials. He sent the journalist, for example, according to a cold clear production enterprises need to use moroxydine as auxiliary materials, but only one or two enterprises producing this kind of active pharmaceutical ingredients, prices from the original one or two Wan Yuanbiao rose to one million yuan per ton, "very unusual". 

 

Not only that, stricter drug enforcement standards have also led to a sharp increase in drug production costs. Liu yun said, before regulators to component testing effect was only 1 tons notoginseng can produce about 5000, 2012, to detect the contents of standards to strict inspection, require each drug contains 1 g of notoginseng, results 1 tons notoginseng can produce 1000 pieces. Plus the three or seven raw materials that have been Fried over the past few years have dramatically increased production costs. Some drugs are caused by technology to improve the cost increase, before a dollar could buy cold spirit, it is because of process adjustment, production cost and selling price, do not want to do at a loss of trade enterprises simply gave up production. 

 

Guangdong zhanjiang a drug firms, chairman of the "daily economic news" reporter said, was helpless to stop supply, in recent years, Chinese herbal medicine prices rose sharply, pushing up the cost of production. At the moment, some of the prices of some medicines are not enough to buy raw materials. If you supply goods by contract, you will lose money as well as not profit. 

 

The monopoly of raw materials is a deep-rooted cause 

 

More than the "daily economic news" reporter interview, head of the pharmaceutical production enterprise are mentioned, API monopoly has become a pharmaceutical raw materials rise in price of an important factor. 

 

"When dopamine is required to be produced, the manufacturer becomes less, the distributor has a monopoly on raw materials, and vitamin B1 is the case." Guangdong a drug firms bidding, head of Mr Zhang told reporters that the dealer monopoly leads to rising cost of active pharmaceutical ingredients but because of government regulations, lower drug prices cannot ascend, enterprises can not normal production. 

 

During the NPC and CPPCC this year, China association for medical supplies, good doctor pharmaceutical group chairman, vice chairman of GengFu can be submitted in its "about the national related department to break monopoly, 'proposals to bring down the price of the said part of the API production enterprise and business enterprise, using the method of the pharmaceutical administration law and relevant regulations" shall manage the approval number of drug substances, its formulation production approval number of active pharmaceutical ingredients "must be used, use hand grasp the approval number of resources, to improve the API prices, or take-out (only for yourself production raw material, cause drug prices artificially high market preparations or common people cannot buy some life-saving medicine. 

 

He also pointed out that the combination of some pharmaceutical companies and individual producers of exclusive raw materials raised prices by nearly 840 per cent. There are also pharmaceutical companies that talk about the total generation of companies with foreign companies for higher prices, which leads to a rise of 677%, some of which are up 1566% in three years. 

 

In fact, the national development and reform commission has also stepped in to clean up the drug monopoly. In 2016, the national development and reform commission of huazhong pharmaceutical co., shandong sym, changzhou SiYao three companies to reach and implement estazolam API, tablet in monopoly agreements made in accordance with the law to punish, total fines exceeds 2.6 million yuan. 

 

Although countries show the attitude to the anti-monopoly enforcement the strength of the pharmaceutical industry, but some API price momentum of still more API prices soaring caused tensions growing upstream enterprise supply and demand. From October 2011 to May 2013, the price of the main raw material, thymol, went from 275 yuan/kg to 8808 yuan/kg, up 32 times. In the first half of the year, the price of the original drug was increased from 75,000 yuan per kilogram in September 2014 to 400,000 yuan per kilogram in January 2015. Pan Li ketone API for Indian companies production as an example, the only two imported exclusive distributor, the price from 900 yuan/kg in two years all the way up to 7000 yuan/kg. 

 

The "double squeeze" of the price of raw materials and the price of the bid on the drug production companies, which hurts companies, will only eventually lead to a partial break. Reporter according to the guangdong medicine center announced the list of statistics, 1004 product rules of drugs in 711 is urgent (rob) save, clinical medicine and cheap drugs, including urgent (rob) save medicine 61 species, 32 species of clinical must and procurement difficulties, cheap medicine 335 species, 283 kinds of other base product. 

 

On May 3, and 4, the daily economic news "reporter repeatedly call open guangdong medicine delivery center, hope to know the number of drug delivery is not timely and not supply manufacturers and explain the reason, but by the time still did not get in touch. The ministry of health and family planning in guangdong province said that the situation of the drug delivery center should be consulted with the relevant departments before responding to the press release.